Bacterial Phenotype Variants in Group B Streptococcal Toxic Shock Syndrome1

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Bacterial Phenotype Variants in Group B Streptococcal Toxic Shock Syndrome1

We conducted genetic and functional analyses of isolates from a patient with group B streptococcal (GBS) necrotizing fasciitis and toxic shock syndrome. Tissue cultures simultaneously showed colonies with high hemolysis (HH) and low hemolysis (LH). Conversely, the HH and LH variants exhibited low capsule (LC) and high capsule (HC) expression, respectively. Molecular analysis demonstrated that t...

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Streptococcal Toxic Shock Syndrome Manifesting

Group A Streptococcus (GAS) is known to cause infections such as pharyngitis, pneumonia, impetigo, erysipelas, necrotizing fasciitis, and septicemia, and can be complicated by rheumatic fever, glomerulonephritis, and erythema nodosum [1]. In 1987, Cone et al described two patients with severe GAS infections who had clinical features similar to staphylococcal toxic shock syndrome (TSS). This syn...

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Group B Streptococcal Toxic Shock Syndrome and covR/S Mutations Revisited

Gene mutations in the virulence regulator CovR/S of group A Streptococcus play a substantial role in the pathogenesis of streptococcal toxic shock syndrome. We screened 25 group B Streptococcus (GBS) isolates obtained from patients with streptococcal toxic shock syndrome and found only 1 GBS clone harboring this kind of mutation.

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ژورنال

عنوان ژورنال: Emerging Infectious Diseases

سال: 2009

ISSN: 1080-6040,1080-6059

DOI: 10.3201/eid1502.080990